Summary
(This study is closed to new patients at the site, please see the Clinical Trials.Gov link below for more information) The purpose of the Phase I portion of this study is to test the safety and side effects of a study drug called Ruxolitinib. Different doses of Ruxolitinib will be studied to see which dose is safe and well tolerated with standard doses of carboplatin and paclitaxel.
Description
The main purpose of the Phase II portion of this study is to compare the effectiveness of the combination of Ruxolitinib with chemotherapy (carboplatin and paclitaxel) to the effectiveness of chemotherapy alone. Another purpose of this Phase II portion is to collect and store tumor tissue and blood samples for future research to evaluate whether specific tests can predict in which patients Ruxolitinib may be more effective.
Principal Investigator
Study Coordinator
Research Contact
Jongie Shelton - jongie.shelton@vandaliahealth.org